Stem cell exosomes and secretome can produce the same therapeutic and rejuvenating effects on skin as live stem cells. Stem cell exosomes are advantageous as they are not live or immunogenic. Mesenchymal Stem Cells (MSCs) secrete exosomes and secretome that contain cytokines and different growth factors such as Epithelial Growth Factor (EGF) and Basic

Fibroblast Growth Factor (bFGF). The exosomes and secretome are well known to be a reliable source of important nutrient and growth factors for skin rejuvenation and wound healing by collagen synthesis of Human Dermal Fibroblasts (HDFs), fibroblast migration and angiogenesis.